Benha University, Egypt
Title: Antioxidants for female infertility: Review of systematic reviews
Dr. Aboubakr Elnashar is a Professor of Obstetrics and Gynecology at Benha University, Egypt. He is the President of clinical society of obs and gyn. He is the member of the board of Egyptian Society of Fertility & sterility from 2015 and till now. He is the editor of the Egyptian Fertility sterility Journal and the Benha Medical Journal. He is the Associate Editor of Middle East fertility Society Journal. He was the assistant secretary general of Egyptian society of fertility & Sterility (2002- 2006). Dr. Elnashar had many publications both national and international. He is managing and directing of many training courses in cytology, colposcopy, ultrasonography, foetal monitor, reproductive endocrinology and ART. Qualification includes, M.B.CH.B. (Very good with honor, 1978, Zagazig University) Post graduate qualifications 1. Master in Ob/Gyn (Very good, 1982), Zagazig University 2. Diploma in cervical pathology (1986, Barcelona, Spain) 3. Medical Doctora in Ob/Gyn (1989, Zagazig University) Post graduate appointments Registrar, assistant lecturer, Lecturer, Assistant professor Ob/Gyn in Benha Faculty of Medicine from January 1996. Appointments 1. Professor of Ob/Gyn, Benha Faculty of Medicine, Egypt, from March 2001 till now 2. Chief of early detection of cancer unit, Benha University Hospital, Egypt. 3. Consultant of IVF &ICSI in Delta Fertility Center & Benha Fertility Center, Egypt.
Main results and the role of chance: Three Cochrane SR and Three non Cochrane SR. Evidence was insufficient to support the use of pentoxifylline in the management of endometriosis in terms of subfertility and relief of pain outcomes. 2. There is some but limited evidence for the beneficial effects of vitamin D supplementation on menstrual dysfunction in polycystic ovary syndrome (PCOS) 3. Myo-inositol provided a beneficial effect for PCOS. 4. Antioxidants; were not associated with an increased life birthrate (LBR) compared with placebo or no treatment. 5. Combined antioxidants were associated with clinical pregnancy rate (CPR). 6. An association was seen between antioxidants and CPR in women with PCOS; however, heterogeneity was extremely high. 7. No association was seen between antioxidants and CPR in women with endometriosis or unexplained infertility. 8. Pentoxifylline was found to be associated with an increased CPR. Limitations, reasons for caution: Despite numerous advances in antioxidant, there is a need for further randomized controlled studies within a larger population to determine their efficacy and safety.Wider implications of the findings: Antioxidants are readily available, mostly unregulated. Significant number of infertile females is taking antioxidants in the expectation that this will improve their chances of conception